Targeting the neuropeptide Y system in stress-related psychiatric disorders
نویسندگان
چکیده
Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many negative physical and psychological outcomes. Stressors can precipitate the onset of psychiatric diseases, or exacerbate pre-existing disorders including various anxiety and mood disorders. As stressors can negatively impact human psychiatric health, it is essential to identify neurochemicals that may confer protection from the negative sequelae of repeated or extreme stress exposure. Elucidating the neurobiological underpinnings of stress resilience will enhance our ability to promote resilience to, or recovery from, stress-related psychiatric disease. Herein, we will review the evidence for neuropeptide Y as an endogenous mediator of resilience and its potential relevance for the treatment of stress-related psychiatric diseases.
منابع مشابه
Neuropeptide Y: Biomarker and intervention for surgical recovery
We read with interest Enman et al.'s recent publication on Neuropeptide Y (NPY) as a therapeutic target for stress-related psychiatric diseases (Enman et al., 2015). They observe that NPY has the potential to provide novel pharmacological therapy for stress-related psychiatric diseases and may have few peripheral side-effects and drugedrug interactions. Moreover, despite its short half-life, NP...
متن کاملO6: Pathophysiology of Anxiety Disorders
The most important risk factors for anxiety disorders include genes, early life stress, and current stress. These factors do not act independently but interact with each other throughout human development through examples such as epigenetic modifications and complex forms of learning. The neural substrate of pathological anxiety includes hyperactivity in the amygdala and other limbic brain regi...
متن کاملCardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers
Exposure to stress or traumatic events can lead to the development of depression and anxiety disorders. In addition to the debilitating consequences on mental health, patients with psychiatric disorders also suffer from autonomic imbalance, making them susceptible to a variety of medical disorders. Emerging evidence utilizing spectral analysis of heart rate variability (HRV), a reliable non-inv...
متن کاملResponse to neuropeptide Y: Biomarker and intervention for surgical recovery
We would like to submit the following response to the authors on the commentary submitted: Neuropeptide Y: biomarker and intervention for surgical recovery. The authors thank Zhao et al. for their interest in our review of neuropeptide Y as a pharmacological target for psychiatric disease and for their commentary entitled “Neuropeptide Y: biomarker and intervention for surgical recovery”. As no...
متن کاملInteractions of Circadian Rhythmicity, Stress and Orexigenic Neuropeptide Systems: Implications for Food Intake Control
Many physiological processes fluctuate throughout the day/night and daily fluctuations are observed in brain and peripheral levels of several hormones, neuropeptides and transmitters. In turn, mediators under the "control" of the "master biological clock" reciprocally influence its function. Dysregulation in the rhythmicity of hormone release as well as hormone receptor sensitivity and availabi...
متن کامل